99% Galantamine Hydrobromide Treating Poliomyelitis Muscle Atrophy

Model: 1953-04-4
Place of Origin: Guangdong,China (Mainland)
Molecular Formula: C17H21NO3.HBr
Molecular Weight: 368.27

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Product Description

Payment & Shipping Terms Supply Capacity
Unit Price:1.0 USDProduction Capacity:1000kg/month
Trade Term:FOB,CFR,CIFPacking:25kg/Drum
Payment Terms:Bitcoin, T/T, WU, Money GramDelivery Date:4days
Min. Order:10 Gram
Means of Transport:Ocean, Air, Land

English name: Galantamine Hydrobromide

Galanthamine hydrobromide (1: 1); (4aS, 6R, 8aS) -6-hydroxy-3-methoxy-11-methyl-5,6,9,10,11,12-hexahydro, galantamine hydrobromide; Benzauro [3a, 3,2-ef] [2] benzazepin-11-ium; Galanthamine HBr

Extraction Source: Lycoris

Galanthamine hydrobromide

CAS: 1953-04-4

EINECS: 217-780-5

Molecular formula: C17H21NO3.HBr

Molecular weight: 368.27

Traits: white crystalline powder; odorless, bitter taste.

Solubility: soluble in water, slightly soluble in ethanol, insoluble in chloroform, ether.

Melting point: 258 ° C to 264 ° C

Boiling point: 439.336 ° C at 760 mmHg

Flash point: 219.503 ° C

Vapor pressure: 0 mmHg at 25 ° C

Detection method: high performance liquid chromatography detector (HPLC)

Specifications: (HPLC) ≥ 99%

Storage: closed, cool and dry, dark, avoid high temperature, the shelf life of two years.



Introduction


Galantamine hydrobromide is the hydrobromide salt of galantamine and is a cholinesterase inhibitor can be extracted from Amaryllidaceae Lycoris plant. The III-phase clinical trials in the United Kingdom in 1998 have showed that this drug had dual mechanism of action of both inhibiting acetylcholinesterase and regulating nicotinic receptors. Therefore, galantamine can improve the cognitive abilities of Alzheimer's patients and has been already applied as the drug of the treatment of mild to severe Alzheimer's disease (AD)  and has entered into market in EC countries. "Chinese Pharmacopoeia" has included the both the raw material and injection of galantamine hydrobromide. It is clinically mainly used for the treatment of poliomyelitis (polio) sequelae, muscular dystrophy and myasthenia gravis. It can be used to substitute neostigmine methyl-sulfate for antagonism of tubocurarine but with weak performance with the usage amount being ten times as high as the usage amount of neostigmine methyl-sulfate. Intravenous injection of 0.5 mg/kg of galantamine hydrobromide can quickly reverse the central anticholinergic effects caused through injection of scopolamine hydrobromide. It can also be used for treating children cerebral palsy, traumatic sensorimotor disorders, multiple neuritis and radiculitis.



Application


Galantamine Hydrobromide is used in treating sequelae of poliomyelitis.

1) strong effect on the central nervous system 

2) recover neuromuscular conduction,improve various paralysis of peripheral neuromuscular disorder 

3) used in the treatment of poliomyelitis (polio) sequela,muscle atrophy and myasthenia gravis etc.


Category: Pharmaceuticals


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