Cas No. 114471-18-0 Molecular Formula C143H244N50O42 S4 Molecular Weight 3464.04 Purity (HPLC) 98.0%min.

Place of Origin: Guangdong,China (Mainland)
Brand Name: Jiazhinuo
Purity: 99

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Product Description

Payment & Shipping Terms Supply Capacity
Unit Price:1.0 USDProduction Capacity:1000t/month
Trade Term:FOB,CFR,CIFPacking:discreet packing
Payment Terms:Bitcoin, T/T, WU, Money GramDelivery Date:ASAP
Min. Order:10 vials
Means of Transport:Ocean, Air, Land

Basic info:

Nesiritide Acetate (BNP-32)
Synonyms:Natriureticpeptide,brain;Brain natriuretic peptide, human;Brain natriuretic peptide (1-32), human;Brain natriuretic peptide-32;Brain natriuretic peptide-32 (human);Brain(b-type) natriuretic peptide-32 (human);B-type (brain) natriuretic peptide-32 (human);Bnp human
Cas No. 114471-18-0
Molecular Formula C143H244N50O42 S4
Molecular Weight 3464.04
Purity (HPLC) 98.0%min.
Appearance White powder
Single Impurity(HPLC) 1.0%max
Amino   Composition ±10% of theoretical
Peptide Content(N%) ≥78.0%
Water Content(Karl Fischer) ≤6.0%
Acetate Content(HPIC) ≤15.0%
MS(ESI) Consistent
Mass Balance 95.0~105.0%
Usage: Hemostatic, Antimicrobial



Description

Nesiritide (Natrecor) is the recombinant form of the 32 amino  human B-type natriuretic peptide, which is normally produced by the ventricular myocardium. Nesiritide works to facilitate cardiovascular fluid homeostasis through counterregulation of the renin-angiotensin-aldoesterone system, stimulating cyclic guanosine monophosphate, leading to smooth muscle cell relaxation.


Neseritide was believed initially to be beneficial for acute decompensated congestive heart failure. It received approval from the United States' Food and Drug Administration for this purpose in 2001 after initial non-approval. In July 2011 the results of the largest study so far for nesiritide was published in The New England Journal of Medicine; it showed that nesiritide was not associated with a change in mortality or re-hospitalizations.


In 2005, after several academic papers published by Jonathan Sackner-Bernstein on the efficacy and side effects of Nesiritide, Johnson & Johnson met with the FDA and altered its stated plans for the drug and agreed to revise its labeling.


Heart doctors at the Cleveland Clinic then voted unanimously not to permit the prescription of the drug to its patients.Following this, the United States Department of Justice announced an inquiry into the marketing of the drug.


Nesiritide of synthetic recombinant human B -type natriuretic peptide (recombined human B-type natriuretic peptide, rhBNP), and ventricular natural natriuretic peptide secretion sodium has the same 32 amino sequence . Nesiritide with guanylyl vascular smooth muscle and endothelial cells cyclase receptors, increase intracellular cGMP content , cGMP as a second messenger to make arteriovenous expansion. Studies have shown that nesiritide make endothelin or α- adrenergic receptor agonist treatment of isolated human artery and vein dilation . In the human body, nesiritide dose- dependent reduction in heart failure patients with pulmonary capillary wedge wedge pressure (pulmonary capillarywedge pressure, PCWP) and arterial pressure.


Applications:

Mainly has a strong angiotensin II vasoconstriction and increase in blood pressure. The mechanism is: 1. So that the body arteriole smooth muscle contraction, increased peripheral resistance; 2. So increase the release of adrenal aldosterone, causing sodium retention, increased blood volume; 3. Directly contribute to renal tubular sodium and water reabsorption; 4. So the brain central nervous sympathetic vasoconstrictor activity, causing increased peripheral vascular resistance; 5. Stimulate the adrenal medulla to release epinephrine and norepinephrine


COA

Product NameNesiritide Acetate (BNP-32)
Cas No.114471-18-0
Molecular FormulaC143H244N50O42 S4
Molecular Weight3464.04
Purity (HPLC)97.0%min.
AppearanceWhite powder
Single Impurity(HPLC)1.0%max
Amino   Composition±10% of theoretical
Peptide Content(N%)≥78.0%
Water Content(Karl Fischer)≤6.0%
Acetate Content(HPIC)≤15.0%
MS(ESI)Consistent
Mass Balance95.0~105.0%




Peptides
Specification
MGF2mg
PEG MGF2mg
CJC-1295 with DAC2mg
CJC-1295 without DAC2mg
PT-14110mg
MT-110mg
MT-210mg
GHRP-25mg
GHRP-210mg
GHRP-65mg
GHRP-610mg
Ipamorelin2mg
Hexarelin2mg
Sermorelin2mg
Oxytocin2mg
TB5002mg
Pentadecapeptide BPC 1572mg
Triptorelin2mg
Tesamorelin2mg
Gonadorelin2mg
Gonadorelin10mg
DSIP2mg
Selank5mg

Finished steroid oil
Strength
Test prop100mg/ml
Test e250mg/ml 300mg/ml
Test cyp250mg/ml 300mg/ml
Test Suspension100mg/ml
 200mg/ml 250mg/ml 300mg/ml
Deca200mg/ml 250mg/ml
NPP100mg/ml 150mg/ml
Equipoise200mg/ml 250mg/ml 300mg/ml
Tren ace100mg/ml
Tren en100mg/ml 200mg/ml
Masteron100mg/ml 150mg/ml
Primobolone100mg/ml
Supertest 450450mg/ml
Anomass 400400mg/ml
Rippex 225225mg/ml
Tri Tren 180180mg/ml
Tri Test 300300mg/ml
Tri Deca 300300mg/ml
Test Blend 450450mg/ml
Test Blend 500500mg/ml
Nandro Test 225225mg/ml
Mass 500500mg/ml
Cut Depot 400400mg/ml
Tren Test 225225mg/ml
Nandro Test Depot 450450mg/ml
Equi Test 450450mg/ml
Rip Cut 175175mg/ml
Tren Test Depot 450450mg/ml



Packaging & Delivery:
We have professional team for package and shipment. Special way to ship 1 gram to 100kg powders/oil at one time to your country. Fast and discreet shipment could be arranged for customs pass Guaranteed.

The Payment We Accept:

Order step:

1:After our quation ,you will choose to accept or not.

2:If you decide to have a try, choose a payment method to pay for the order.

3:We will sent the package out in 24hours after we received the payment ,then will sent the tracking number with packaging detail to you via mai.

4:We will help track the package until you receive it successful,if accident happen ,we will see the reason to decide re-sent for free or half-price re-sent.


Our Competitive Advantages:
1. Rich experience: we specialize in this field for many years, our steroids have been exported almost over the world. Such as USA, Canada, UK, Brazil, Germany, Russia, Australia, Greece, Poland, Bulgaria, Rumania, Netherlands, Sweden, Ukraine, Latvia, Lithuania, Ireland, Austria, Iran, Turkey, Mexico, Thailand, India, Malaysia, Singapore, other Middle East countries, European countries, American countries and more Areas.
2. Great quality: High purity and Favorable price. Good quality is the first base of our success. All of our products enjoys high purity. Thus, it can make sure your demand. Welcome order the samples, MOQ just 10 grams.
3. Safe and fast delivery: Lots of different discreet safe packing methods, experience in choosing express, 4~7 days to arrive, successful rate 99%.
4. Experiential order and cooperation: Besides raw powders, we offer hormone solution and Recipes. We can teach you or discuss how to make hormone solution on the site. Any discussion and question is welcome!
Packaging & Service:
1. Mass stock, to make sure delivery promptly every day when the payment is done.
2. Having been engaged in this field for years, we have sophisticated and professional logistics department, which can guarantee safe and speedy delivery.
3. Well-trained and disciplined packing team which is professional enough to provide you a safe package. It also avoid a lot of emergency happen during the delivery so that high customs pass is guaranteed. Unique ways to ship 10grams to 20 kilograms powders(or 100ml to 30 Liter liquids) at one time to your destination.
4. Packing pictures and tacking number are provided within 24 hours as soon as receiving the payment. Updated tracking code will be provided every other day just for you can hold a palm of your package.
5. Perfect after-sale service: Any questions or problems happened after receiving the product.
Please feel free to contact us. 24/7 online to solve your various problems!


Category: Protein Peptide Hormones


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