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English Name: Memantine HCl
Molecular formula: C12H22ClN
Molecular weight: 215.76
WHAT IS Memantine HCL?
Memantine hydrochloride is developed by German Merz company to treat dementia d rugs, is a new type of low, moderate affinity, voltage dependent and non competitive N methyl D aspartate (NMDA) receptor antagonist can noncompetitive NMDA receptor blockade induced by glutamate receptor NMDA, reduce the excessive excitement, prevent cell apoptosis, improve memory, is a new generation of dr ugs to improve cognitive function.
In February 2002, the European Commission (CPMP) approved the drug patent for moderate to severe Alzheimer's disease treatment, in August of the same year in the German market, in October 17, 2003 by the U.S. Food and Drug Administration (FDA) approved for the treatment of moderate to severe Alzheimer's disease patients.
Further studies show that memantine hydrochloride is effective for mild to moderate Alzheimer's disease. Alzheimer's disease (Alzheimer, disease, AD), also known as Alzheimer's disease, is one of the common diseases of the elderly, mainly for the loss of memory and ability to identify barriers, is a progressive neurological degenerative disease. Memantine hydrochloride is approved for the treatment of Alzheimer's disease.
Memantine hydrochloride as chemicals, the lack of some basic physical data, can refer to adamantane, amantadine hydrochloride, 1 3-, two methyl adamantane performance that memantine hydrochloride can be dissolved in organic solvent, slightly soluble in water. Low toxicity, no irritation to the skin, eyes and mucous membranes, but must be used under the guidance of a doctor as a drug and must not be swallowed at will
Memantine hydrochloride is a kind of pharmaceutical raw materials, into a tablet called "easy times Shen, the product should be on the diagnosis and treatment of Alzheimer type dementia experienced prescription and guide the patients to use. There are patients with medication on time to supervise the case of starting treatment of caregivers. Dementia should be diagnosed in accordance with current diagnostic criteria and guidelines.
Used in combination with other d rugs
1. and huperzine a combined use of: huperzine A is a drug extracted from traditional Chinese medicine huperziaserrata, as reversible competitive inhibitors of cholinesterase. Memantine have different binding capacity of different subtype of glutamate receptor or ion channel, reducing the role of glutamate excitotoxicity, and treatment of AD. AD patients not only have many neurotransmitter changes, but also have postsynaptic receptor abnormalities, so the use of cholinesterase inhibitors and glutamate receptor inhibitors can play a synergistic effect.The combination of
2. and donepezil: donepezil second generation inhibitor of cholinesterase, high selectivity, on the central nervous system, Che long half-life, is more toxic than huperzine a. Donepezil and huperzine A act on different nerve conduction systems and can produce synergistic effects when combined with the two, thereby enhancing efficacy. Although the special mechanism has not been found, but the fact that patients with moderate to severe AD in the use of memantine hydrochloride combined with other d rugs treatment, will have a better therapeutic effect.
3. combined with nimodipine: nimodipine belongs to two dihydropyridine Ca2+ antagonists, acting on nerve cells in the central nervous system, cerebral vascular cells and glial cells, can obviously dilate cerebral vessels and meningeal vascular diameter, to a certain extent can be delayed in patients with cognitive decline. When combined with nimodipine and memantine hydrochloride, the pharmacological effects and mechanism of different link role had complementary advantages, resulting in better curative
4.The combination of 4. main components: Ginkgo biloba and Ginkgo biloba flavonoids in Solanaceae and lipid compounds having antithrombotic, anticoagulant, antiplatelet, antioxidant and lipid metabolism, improve vascular permeability and reduce brain injury and have protective effects on cerebral microvascular smooth muscle cells, with obvious protective effects on  "vascular damage. Role of vascular factors in the pathogenesis of AD is gradually being taken seriously, a large number of epidemiological and clinical and basic research showed that the risk factors associated with many factors or vascular hemodynamics can increase the risk of AD. Therefore, can play a synergistic effect in combination with the function of NMDA receptor in memantine hydrochloride and Ginkgo biloba.
With memantine hydrochloride overview, characteristics, synthesis methods of Chemicalbook by Shi Yan edited. (2015-11-02)
Category: No otropic Raw Powder